Ammonium Hydroxide → HCID 21584299、化合物

HRID 369956ノート

反応式

HRID 369956 の反応式
[CH2:1]1[CH:10]2[N:5]([C:6](=[O:15])[C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9]2)[CH2:4][CH2:3][CH2:2]1.[N+:16]([O-])([O-:18])=[O:17].[K+].[OH-].[NH4+]>S(=O)(=O)(O)O>[N+:16]([C:13]1[CH:12]=[CH:11][C:8]2[CH2:9][CH:10]3[N:5]([C:6](=[O:15])[C:7]=2[CH:14]=1)[CH2:4][CH2:3][CH2:2][CH2:1]3)([O-:18])=[O:17]

参加物

5

反応物 3

HCID 14923Ammonium HydroxideHCID 24434Potassium NitrateHCID 27527926H-Benzo[b]quinolizin-6-one, 1,2,3,4,11,11a-hexahydro-

生成物 1

HCID 21584299HCID 21584299、化合物収率 92%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

1,3,4,6,11,11a-Hexahydro-2H-benzo[b]quinolizin-6-one (3.78 g, 18.7 mmol) was dissolved in concentrated sulfuric acid (50 ml) at 0° C., potassium nitrate (2.02 g, 20 mmol) was added and the reaction mixture was stirred overnight. The reaction mixture was poured onto ice (200 g) and was partially neutralized with concentrated ammonium hydroxide. The precipitate was collected and air-dried to give the title compound as a yellow solid (4.22 g, 92%), m.p. 137-42° C.

後処理

  1. additionThe reaction mixture was poured onto ice (200 g)
  2. customThe precipitate was collected
  3. customair-dried

出典と根拠

ORDレコード
ord-0bae4172384c471681c83b9d4bcfa88f
出典データセット
uspto-grants-2000_10
特許番号
US06140322

反応ノート

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