Hydrochloric Acid → 2-Methylbenzenesulfonic acid

HRID 370007ノート

反応式

HRID 370007 の反応式
N#[C-].N[C:4]1[CH:12]=[CH:11][C:7]([C:8](N)=N)=[CH:6][CH:5]=1.Cl.[S:14](=O)(=[O:17])([OH:16])[OH:15].B(F)(F)F.CCOCC>O.C(O)(C)C.O1CCCC1.O1CCOCC1.C(O)C.CO>[C:7]1([CH3:8])[C:6]([S:14]([OH:17])(=[O:16])=[O:15])=[CH:5][CH:4]=[CH:12][CH:11]=1

参加物

12

反応物 5

HCID 313Hydrochloric AcidHCID 1118Sulfuric AcidHCID 1725p-AminobenzamidineHCID 5975CyanideHCID 8000Boron trifluoride etherate

生成物 1

HCID 69252-Methylbenzenesulfonic acid

試薬・触媒・溶媒 6

HCID 702Ethanol溶媒HCID 887Methanol溶媒HCID 962Water溶媒2 回HCID 3776Isopropanol溶媒2 回HCID 8028Tetrahydrofuran溶媒2 回HCID 312751,4-Dioxane溶媒

実験手順

The reaction of a substituted benzaldehyde of the formula II, an isonitrile of the formula RNC and a 4-aminobenzamidine of the formula III is advantageously carried out in a solvent (e.g. methanol, isopropanol, ethanol, dioxane, or tetrahydrofuran), or in a solvent mixture (e.g. tetrahydrofuran and water or isopropanol and water), advantageously by using an inorganic acid (e.g. hydrochloric acid, sulphuric acid or boron trifluoride etherate), or an organic acid (e.g. toluenesulphonic acid), or in acidic ion exchanger (e.g. Amberlyst K10) as catalyst, at a temperature between 0° C. and 100° C., giving compounds of the formula I. The reaction of a substituted aldehyde of the formula II, of an isonitrile of the formula R1NC and 4-aminobenzonitrile under similar reaction conditions leads to compounds of the formula IV in which Q is hydrogen.

出典と根拠

ORDレコード
ord-ad53b657205646afaa67ccde8672ba4f
出典データセット
uspto-grants-2000_10
特許番号
US06140353

反応ノート

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