Nitric Acid → 3,5-Dichloro-2-nitrobenzoic acid

HRID 370090

反応式

HRID 370090 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:11])[CH:10]=1)[C:5]([OH:7])=[O:6].[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:3]([N+:12]([O-:14])=[O:13])=[C:4]([CH:8]=[C:9]([Cl:11])[CH:10]=1)[C:5]([OH:7])=[O:6]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 58113,5-Dichlorobenzoic acid

生成物 1

HCID 52108523,5-Dichloro-2-nitrobenzoic acid収率 90%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

To a solution of 3,5-dichlorobenzoic acid (50 g, 0.26 mol) in sulfuric acid (250 mL) at 0° C. was added nitric acid (18 g, 0.28 mol) dropwise, and the mixture warmed slowly to ambient temperature. After 5 hours the mixture was poured onto ice, and the white precipitate collected by filtration. The solid was washed with water (3×30 mL), and dried in vacuo to afford 55 g (90% yield) of 3,5-dichloro-2-nitrobenzoic acid; NMR (CDCl3) 8.3 (s, 1), 8.0 (s, 1) ppm.

後処理

  1. additionAfter 5 hours the mixture was poured onto ice
  2. filtrationthe white precipitate collected by filtration
  3. washThe solid was washed with water (3×30 mL)
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-870f3e13df194581981554d219872489
出典データセット
uspto-grants-2000_10
特許番号
US06140351

関連ノート

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