Boron trifluoride etherate → 2,3,5,6-Tetrafluorophenyl trifluoroacetate

HRID 37028

反応式

HRID 37028 の反応式
F[C:2]([F:13])(F)[C:3]([O:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8])=O.[F:14][C:15]1[C:20]([F:21])=CC(F)=[C:17]([F:23])[C:16]=1O.B(F)(F)F.CCOCC>>[F:10][C:7]([F:8])([F:9])[C:6]([O:5][C:3]1[C:2]([F:13])=[C:17]([F:23])[CH:16]=[C:15]([F:14])[C:20]=1[F:21])=[O:11]

参加物

4

反応物 3

HCID 8000Boron trifluoride etherateHCID 9845Trifluoroacetic anhydrideHCID 698582,3,5,6-Tetrafluorophenol

生成物 1

HCID 153342582,3,5,6-Tetrafluorophenyl trifluoroacetate収率 75%

実験手順

Trifluoroacetic anhydride (28 mL, 0.2 mol) was added dropwise with stirring to 27.1 g (0,163 mol) of 2,3,5,6tetrafluorophenol. Boron trifluoride etherate (0.2 mL) was added and the mixture was refluxed overnight. The residual solution was distilled at atmospheric pressure to remove trifluoroacetic anhydride and trifluoroacetic acid. The desired product 18 (32.2 g; 75% yield) was collected at 45° C. (18mm) as a colorless liquid:

後処理

  1. temperaturethe mixture was refluxed overnight
  2. distillationThe residual solution was distilled at atmospheric pressure
  3. customto remove trifluoroacetic anhydride and trifluoroacetic acid

出典と根拠

ORDレコード
ord-0f9b25f93fa74c2990bd28e8b3c03f57
出典データセット
uspto-grants-1995_05
特許番号
US05419966

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