Sodium Hydroxide → 5-Benzofuranacetic acid

HRID 37036ノート

反応式

HRID 37036 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]([O:13]C)=[O:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[OH-].[Na+]>CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]([OH:13])=[O:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 19748760Methyl 2-(benzofuran-5-YL)acetate

生成物 1

HCID 234388925-Benzofuranacetic acid収率 99.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl benzofuran-5-ylacetate (1.2 gm, 6.3 mmol) was dissolved in methanol (10 mL) and 2N sodium hydroxide (6.5 mL) was added under nitrogen and the mixture was stirred at rt for 3 hr. It was then diluted-with water and extracted with ether. The aqueous layer was acidified with 2N hydrochloric acid and again extracted twice with ethyl acetate. The organic layers were washed with brine, combined, dried over sodium sulfate and evaporated to give 1.1 gm of title compound suitable for the next step.

後処理

  1. extractiondiluted-with water and extracted with ether
  2. extractionagain extracted twice with ethyl acetate
  3. washThe organic layers were washed with brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-e1f85173cb4b40e7912ff01baf9a6454
出典データセット
uspto-grants-1995_05
特許番号
US05420010

反応ノート

読み込み中…