Propargyl alcohol → N-Desethyloxybutynin, (S)-
反応式
C1(C(C2C=CC=CC=2)(O)C(O)=O)CCCCC1.[CH3:18][CH2:19][N:20]([CH2:23][C:24]#[C:25][CH2:26][O:27][C:28]([C@:30]([OH:43])([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[CH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)=[O:29])CC.C(OC(Cl)=O)C(C)C.C(O)C#C.C(N(C(C)C#CO)CC1C=CC(OC)=CC=1)C.C1(C(C2CCCCC2)(O)C(OC#CCCN(CC)CC2C=CC(OC)=CC=2)=O)C=CC=CC=1.C(Cl)(=O)OC(Cl)C>>[C:31]1([C@:30]([CH:37]2[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]2)([OH:43])[C:28]([O:27][CH2:26][C:25]#[C:24][CH2:23][NH:20][CH2:19][CH3:18])=[O:29])[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1参加物
8
反応物 7
生成物 1
実験手順
The method according to claim 1, wherein said single enantiomer of cyclohexylphenyl glycolic acid is the (S) enantiomer, said alkyl chloroformate is isobutylchloroformate, said sidechain propargyl alcohol derivative of formula (III) is N-ethyl-N-(4-methoxybenzyl)aminobutynol, and said single enantiomer of structure (II) is N-ethyl-N-(4-methoxybenzyl)aminobutynyl phenylcyclohexyl-glycolate, which is treated with α-chloroethyl carbonochloridate to provide (S)-4-ethylamino-2-butynyl phenylcyclohexylglycolate.
出典と根拠
- ORDレコード
- ord-11bf3b40865d45ab89832788d86873e8
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06140529
反応ノート
読み込み中…