Tetrahydrofuran → N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine

HRID 370375ノート

反応式

HRID 370375 の反応式
CN(O)[C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[Cl:20])[CH:6]=[CH:5][C:4]=1[N+:21]([O-:23])=[O:22].C([N:27]([CH2:30]C)CC)C.Cl[CH2:33][O:34][C:35](=[O:37])[CH3:36].C1C[O:41]CC1>>[CH3:30][NH:27][O:41][CH2:33][O:34][C:35](=[O:37])[CH2:36][C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[Cl:20])[CH:6]=[CH:5][C:4]=1[N+:21]([O-:23])=[O:22]

参加物

5

反応物 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 69366Chloromethyl acetateHCID 20275650HCID 20275650、化合物

生成物 1

HCID 86740180N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine

実験手順

To a solution of N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]hydroxyamine (700 mg, 1.93 mmol) in THF (10 ml) containing triethylamine (1.2 eq.) is added chloromethylacetate (2 eq.). The mixture is stirred at RT overnight. Excess THF is removed and the product is evaporated to dryness and purified to give N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine.

後処理

  1. customExcess THF is removed
  2. customthe product is evaporated to dryness
  3. custompurified

出典と根拠

ORDレコード
ord-06264be53c1c4997ae34a1e86f5bd9a6
出典データセット
uspto-grants-1985_07
特許番号
US04526608

反応ノート

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