Sulfuric Acid → [6-(Hydroxymethyl)pyridin-3-yl]methanol

To a solution of 33.5 g (0.15 mol) of diethyl pyridine-2,5-dicarboxylate in 300 mL of absolute EtOH was added 11.4 g (0.3 mol) of NaBH4 in several portions over a 30-min period. Then a solution of 33.3 g (0.3 mol) of anhydrous CaCl2 in 200 ml of EtOH was added dropwise over a 1-h period. The mixture was stirred at room temperature for 16 h, and then it was neutralized with 12 to 13 mL of concentrated H2SO4. The CaSO4, which precipitated, was removed by centrifugation (two EtOH washings). The combined supernatant was concentrated, dissolved in about 10 mL of H2O, and applied to a 4.5×18-cm column of Dowex 50W-X8 cation exchange resin (H+ form). The column was eluted with H2O until the eluate was no longer acidic, and then it was eluted with dilute NH4OH, which removed the 2,5-pyridinedimethanol from the column. Evaporation afforded 10.6 g (51% yield) of 2,5-pyridinedimethanol as a light brown hygroscopic solid: 1H NMR (Me2SO-d6) δ4.55 and 4.59 (2 s, 4, CH2OH), 5.23 (broad s, 2, CH2OH), 7.42 (d, J=8 Hz, 1, 3'--H), 7.72 (dd, J=2 Hz, J=8 Hz, 1, 4--H), 8.42 (d, J=2 Hz, 1, 6'--H).

1. customThe CaSO4, which precipitated
2. customwas removed by centrifugation (two EtOH washings)
3. concentrationThe combined supernatant was concentrated
4. dissolutiondissolved in about 10 mL of H2O
5. washThe column was eluted with H2O until the eluate
6. washit was eluted with dilute NH4OH, which
7. customremoved the 2,5-pyridinedimethanol from the column
8. customEvaporation

ORDレコード

ord-ed760393c94e4fd9b01c9a8a64d4c7c2

出典データセット

uspto-grants-1985_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04526787