Methanol → 2-Methoxy-4-(cyclopropylamino)-6-(1-methylethylamino)-1,3,5-triazine

HRID 370609

反応式

HRID 370609 の反応式
[Na].Cl[C:3]1[N:8]=[C:7]([NH:9][CH:10]2[CH2:12][CH2:11]2)[N:6]=[C:5]([NH:13][CH:14]([CH3:16])[CH3:15])[N:4]=1.[CH3:17][OH:18]>>[CH3:17][O:18][C:3]1[N:8]=[C:7]([NH:9][CH:10]2[CH2:12][CH2:11]2)[N:6]=[C:5]([NH:13][CH:14]([CH3:16])[CH3:15])[N:4]=1

参加物

4

反応物 3

HCID 887MethanolHCID 24738CyprazineHCID 5360545Sodium

生成物 1

HCID 202748622-Methoxy-4-(cyclopropylamino)-6-(1-methylethylamino)-1,3,5-triazine

実験手順

2.1 g of sodium was added in portions to 400 ml of stirred anhydrous methanol. The solution was allowed to cool to room temperature, then 16.5 g of 9B was added and the mixture was refluxed for 2 hours. The solvent was evaporated, and the residue was washed with water, then extracted with ether. The extract phase was dried (MgSO4) and stripped of solvent to give 2-methoxy-4-(cyclopropylamino)-6-(1-methylethylamino)-1,3,5-triazine (13A).

後処理

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent was evaporated
  3. washthe residue was washed with water
  4. extractionextracted with ether
  5. dry with materialThe extract phase was dried (MgSO4)

出典と根拠

ORDレコード
ord-a3dd8f3efd3d43f2ba7a1f82d6b37e86
出典データセット
uspto-grants-1985_07
特許番号
US04528027

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