Methanethiol → Ametryn

HRID 370611

反応式

HRID 370611 の反応式
[Na].[CH3:2][SH:3].[CH3:4][CH2:5][NH:6][C:7]1[N:12]=[C:11](Cl)[N:10]=[C:9]([NH:14][CH:15]([CH3:17])[CH3:16])[N:8]=1>CO>[CH3:2][S:3][C:11]1[N:10]=[C:9]([NH:14][CH:15]([CH3:17])[CH3:16])[N:8]=[C:7]([NH:6][CH2:5][CH3:4])[N:12]=1

参加物

5

反応物 3

HCID 878MethanethiolHCID 2256AtrazineHCID 5360545Sodium

生成物 1

HCID 13263Ametryn

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1 g of sodium was added to 100 ml of dry methanol. The solution was allowed to cool to room temperature, 12 g of methanethiol was added, then 4.5 g atrazine, and the mixture was refluxed for 2 hours. The solvent was evaporated, the residue was dissolved in water, and the solution was extracted with ether. The extract phase was dried (MgSO4) and the solvent was evaporated. The residue was dissolved in a minimum amount of boiling hexane. The solution was cooled and the solid product was collected and dried to give 2-(methylthio)-4-(1-methylethylamino)-6-(ethylamino)-1,3,5-triazine (15A) (Ametryne).

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in water
  3. extractionthe solution was extracted with ether
  4. dry with materialThe extract phase was dried (MgSO4)
  5. customthe solvent was evaporated
  6. dissolutionThe residue was dissolved in a minimum amount of boiling hexane
  7. temperatureThe solution was cooled
  8. customthe solid product was collected
  9. customdried

出典と根拠

ORDレコード
ord-cbe7ab5bfd714a279eaa03515efbabb1
出典データセット
uspto-grants-1985_07
特許番号
US04528027

関連ノート

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