Allyl bromide → 1-(4-Allyloxyphenyl)-2-(4-diphenylmethylpiperazinyl)ethanol

HRID 370664ノート

反応式

HRID 370664 の反応式
[C:1]1([CH:7]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)[OH:16])[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:30](Br)[CH:31]=[CH2:32].[OH-].[K+]>C(O)C>[CH2:32]([O:23][C:20]1[CH:19]=[CH:18][C:17]([CH:15]([OH:16])[CH2:14][N:11]2[CH2:10][CH2:9][N:8]([CH:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:13][CH2:12]2)=[CH:22][CH:21]=1)[CH:31]=[CH2:30]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 14797Potassium HydroxideHCID 30711602-(4-Diphenylmethylpiperazinyl)-1-(4-hydroxyphenyl)ethanol

生成物 1

HCID 103203901-(4-Allyloxyphenyl)-2-(4-diphenylmethylpiperazinyl)ethanol収率 64%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In 1.2 liters of ethanol were dissolved 120 g (0.31 mol) of 2-(4-diphenylmethylpiperazinyl)-1-(4-hydroxyphenyl)-ethanol, 74.8 g (0.62 mol) of allyl bromide and 41 g of potassium hydroxide. The resultant solution was heated with refluxing for one hour. After cooling the solution and then removing the solvent, the residue was added with 1.0 liter of ethyl acetate. The resultant mixture was washed successively with an aqueous 1N solution of sodium hydroxide, water and saturated saline, followed by drying over anhydrous sodium sulfate. The solvent was removed, and the residue was crystallized from a mixed solvent of ethanol and n-hexane to give 84.6 g of 1-(4-allyloxyphenyl)-2-(4-diphenylmethylpiperazinyl)ethanol (yield: 64%).

後処理

  1. temperaturewith refluxing for one hour
  2. temperatureAfter cooling the solution
  3. customremoving the solvent
  4. additionthe residue was added with 1.0 liter of ethyl acetate
  5. washThe resultant mixture was washed successively with an aqueous 1N solution of sodium hydroxide, water and saturated saline
  6. dry with materialby drying over anhydrous sodium sulfate
  7. customThe solvent was removed
  8. customthe residue was crystallized from a mixed solvent of ethanol and n-hexane

出典と根拠

ORDレコード
ord-0aac2fb3855742bda7200f6e4e9e1e46
出典データセット
uspto-grants-1985_07
特許番号
US04528194

反応ノート

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