Hydrochloric Acid → 9-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine hydrochloride

HRID 37087

反応式

HRID 37087 の反応式
[F:1][C@@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][C@H:3]1[N:10]1[CH:18]=[N:17][C:16]2[C:11]1=[N:12][CH:13]=[N:14][C:15]=2[NH2:19].C(O)(C)C.[ClH:24]>CO.O>[ClH:24].[F:1][C@@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][C@H:3]1[N:10]1[CH:18]=[N:17][C:16]2[C:11]1=[N:12][CH:13]=[N:14][C:15]=2[NH2:19]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 1002532'-Fluoro-2'-deoxyadenosine

生成物 1

HCID 677407569-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of 9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)adenine (500 mg. 1.86 mmol) in MeOH (40 ml) and water (10 ml) was added a solution of isopropanol (15 ml) previously saturated with HCl gas. The solution was evaporated under vacuum at room temperature, and triturated with EtOH (25 ml) to afford the title compound as a white solid.

後処理

  1. customThe solution was evaporated under vacuum at room temperature
  2. customtriturated with EtOH (25 ml)

出典と根拠

ORDレコード
ord-6f3bdcf96f5c441380f7fe1672130045
出典データセット
uspto-grants-1995_05
特許番号
US05420115

関連ノート

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