Thionyl Chloride → N-Cyclohexyl 4-Chlorobenzimidoyl Chloride
反応式
[CH:1]1([NH:7][C:8](=O)[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:19])=O>>[CH:1]1([N:7]=[C:8]([Cl:19])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
3
実験手順
N-Cyclohexyl 4-chlorobenzamide (12.8 g, 53.9 mmole) and thionyl chloride (43.14 g, 363 mmole) were heated at reflux with stirring for 1.75 hours. Excess thionyl chloride was removed by distillation. The title compound was isolated by distillation (b.p. 130° C. at ~15 mm Hg) to yield 7.4 g (54%) of a clear colorless liquid which crystallized upon cooling.
後処理
- temperatureat reflux
- customExcess thionyl chloride was removed by distillation
出典と根拠
- ORDレコード
- ord-1a7be2027218483d9b1209200e215c66
- 出典データセット
- uspto-grants-1985_07
- 特許番号
- US04528382
反応ノート
読み込み中…