Thionyl Chloride → N-Octyl 4-Chlorobenzimidoyl Chloride

HRID 370916ノート

反応式

HRID 370916 の反応式
[CH2:1]([NH:9][C:10](=O)[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].S(Cl)([Cl:21])=O>>[CH2:1]([N:9]=[C:10]([Cl:21])[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 17219574-chloro-N-octylbenzamide

生成物 1

HCID 13477601N-Octyl 4-Chlorobenzimidoyl Chloride収率 77%

実験手順

N-Octyl 4-chlorobenzamide (17.2 g, 64.2 mmole) and thionyl chloride (42.59 g, 358 mmole) were stirred and heated at reflux for one hour. The product was isolated by fractional distillation at reduced pressure (b.p. 70°-90° C. at 15 mm Hg) to yield 14.0 g (77%) of impure title compound.

後処理

  1. temperatureheated
  2. temperatureat reflux for one hour
  3. customThe product was isolated by fractional distillation at reduced pressure (b.p. 70°-90° C. at 15 mm Hg)

出典と根拠

ORDレコード
ord-d8717f55b0014481a130076770b05e2f
出典データセット
uspto-grants-1985_07
特許番号
US04528382

反応ノート

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