Sodium Bicarbonate → Clavulanic Acid
反応式
[CH2:1]1[C:4](=[O:5])[N:3]2[C@@H:6]([C:12]([O:14]CC3C=CC=CC=3)=[O:13])/[C:7](/[O:11][C@H:2]12)=[CH:8]/[CH2:9][OH:10].C(=O)([O-])O.[Na+]>C(O)C.[Pd]>[CH2:1]1[C:4](=[O:5])[N:3]2[C@@H:6]([C:12]([OH:14])=[O:13])/[C:7](/[O:11][C@H:2]12)=[CH:8]/[CH2:9][OH:10]参加物
5
実験手順
Substantially pure benzyl clavulanate (281 mg) in ethanol (25 ml.) containing sodium hydrogen carbonate (82 mg.) was hydrogenated over 10% Pd/C (90 mg.) for 25 minutes at room temperature and atmospheric pressure. The catalyst was filtered off, washed with water and ethanol, and the combined filtrates evaporated under reduced pressure at room temperature. The residual semi-solid was triturated with acetone, filtered and washed with ether to yield sodium clavulanate (135 mg.).
後処理
- filtrationThe catalyst was filtered off
- washwashed with water and ethanol
- customthe combined filtrates evaporated under reduced pressure at room temperature
- customThe residual semi-solid was triturated with acetone
- filtrationfiltered
- washwashed with ether
出典と根拠
- ORDレコード
- ord-faf989bd37d84f07bc253fa02b06dd2f
- 出典データセット
- uspto-grants-1985_07
- 特許番号
- US04529720
反応ノート
読み込み中…