Acetic Acid → 1,3-Butanedione, 1-(2-furanyl)-

HRID 371090

反応式

HRID 371090 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8]C)=O.[CH3:10][C:11]([CH3:13])=[O:12].CC(C)([O-])C.[K+].C(O)(=O)C>C1(C)C=CC=CC=1.O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:8])[CH2:10][C:11](=[O:12])[CH3:13]

参加物

7

反応物 4

HCID 176Acetic AcidHCID 180AcetoneHCID 11902Methyl 2-furoateHCID 23665647Potassium tert-butoxide

生成物 1

HCID 121681,3-Butanedione, 1-(2-furanyl)-

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

A mixture of methyl 2-furoate (23 g, 0.18 mole) and acetone (10.6 g, 0.18 mole) was slowly added to a stirred suspension of potassium tert-butoxide (41 g, 0.36 mole) in anhydrous toluene (300 ml) at 0° C. Upon standing overnight at room temperature, glacial acetic acid (22 ml, 0.36 mole) and then water (100 ml) were added. The organic layer was separated, combined with an ether extract of the aqueous phase, washed with water, dried, and distilled to give 1-(2-furyl)-1,3-dioxobutane: b.p. 66°-70° C./0.1 mm (18.5 g).

後処理

  1. customThe organic layer was separated
  2. extractionextract of the aqueous phase
  3. washwashed with water
  4. customdried
  5. distillationdistilled

出典と根拠

ORDレコード
ord-7805c0baa15549b38d0828aa8c242789
出典データセット
uspto-grants-1985_07
特許番号
US04529733

関連ノート

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