Fenbufen → Phthalidyl 4-(4-biphenylyl)-4-oxobutyrate

HRID 371114

反応式

HRID 371114 の反応式
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][C:4]([C:7](=[O:13])[CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:3][CH:2]=1.C(N(CC)CC)C.Br[CH:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:30](=[O:31])[O:29]1>C(Cl)(Cl)Cl>[C:1]1([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:2]=[CH:3][C:4]([C:7](=[O:13])[CH2:8][CH2:9][C:10]([O:12][CH:28]2[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[C:30](=[O:31])[O:29]2)=[O:11])=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 3335FenbufenHCID 8471TriethylamineHCID 962181(3H)-Isobenzofuranone, 3-bromo-

生成物 1

HCID 12769707Phthalidyl 4-(4-biphenylyl)-4-oxobutyrate収率 73%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a solution of 7.5 g of 4-(4-biphenylyl)-4-oxobutyric acid in 40 ml of chloroform and 3.4 g of triethylamine is added a solution of 6.2 g of 3-bromophthalide in 20 ml of chloroform. The solution thus obtained is stirred 24 hours at room temperature, the organic phase is washed with an aqueous solution of sodium bicarbonate, then with water and finally it is dried on anhydrous sodium sulfate and evaporated to dryness to give the phthalidyl 4-(4-biphenylyl)-4-oxobutyrate; yield 73%.

後処理

  1. customThe solution thus obtained
  2. washthe organic phase is washed with an aqueous solution of sodium bicarbonate
  3. dry with materialwith water and finally it is dried on anhydrous sodium sulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-acd74628f258460587cc31e2e8b25646
出典データセット
uspto-grants-1985_07
特許番号
US04529737

関連ノート

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