Cyanoacetamide → Dpn 205-734

HRID 371317ノート

反応式

HRID 371317 の反応式
[C:1]([CH2:3][C:4]([NH2:6])=[O:5])#[N:2].[Na].CN(C)[CH:10]=[C:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][CH:16]=1)[C:12](=O)[CH3:13]>C(O)C>[C:21]([C:18]1[CH:19]=[CH:20][C:15]([C:11]2[CH:10]=[C:3]([C:1]#[N:2])[C:4](=[O:5])[NH:6][C:12]=2[CH3:13])=[CH:16][CH:17]=1)#[N:22]

参加物

5

反応物 3

HCID 7898CyanoacetamideHCID 5360545Sodium2 回HCID 542472714-[1-(Dimethylamino)-3-oxobut-1-en-2-yl]benzonitrile

生成物 1

HCID 145915Dpn 205-734

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

6.2 g of cyanacetamide are added to a freshly prepared solution of 1.14 g sodium in 200 ml of absolute ethanol. 10.6 g 4-dimethylamino-3-(4-cyanophenyl)-3-buten-2-one are added and the solution is stirred 5 hours at boiling temperature, whereby the sodium salt of the title compound soon begins to crystallize out. The mixture is allowed to cool, the crystalline product is filtered and washed with ethanol and ether (m.p. of the sodium salt>300°) (m.p. of the free form>300°).

出典と根拠

ORDレコード
ord-04f35d4ba1034a6c8a0255f24c217fb5
出典データセット
uspto-grants-1985_07
特許番号
US04530842

反応ノート

読み込み中…