Hydrochloric Acid → N-{3-[(1-Chloro-2-nitroethenyl)sulfanyl]propyl}acetamide

反応式

[OH-].[Na+].[SH:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:10])[CH3:9].[Cl:11][C:12](Cl)=[CH:13][N+:14]([O-:16])=[O:15].Cl.[Cl-].[Na+]>CO>[Cl:11][C:12]([S:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:10])[CH3:9])=[CH:13][N+:14]([O-:16])=[O:15]

参加物

反応物 5

HCID 313Hydrochloric Acid

HCID 5234Sodium Chloride

HCID 14798Sodium Hydroxide

HCID 122195711,1-Dichloro-2-nitroethene

HCID 20238484N-(3-Mercaptopropyl)acetamide

生成物 1

HCID 53674132N-{3-[(1-Chloro-2-nitroethenyl)sulfanyl]propyl}acetamide

試薬・触媒・溶媒 1

実験手順

A solution of 0.12 g of sodium hydroxide in 5 ml of methanol was added over 10 minutes to a solution of 0.40 g of 1 in 5 ml of methanol. Then a solution of 0.95 g of 1,1-dichloro-2-nitroethene (13A) in 5 ml of methanol was added over 20 minutes, at 0° C. The mixture then was stirred for 20 minutes and poured into 2% hydrochloric acid saturated with sodium chloride. The resulting mixture was extracted with methylene chloride, the solvent was evaporated and the residue was purified over silica gel to give 13, as an oil.