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Pyridine → 6-Amidino-2-naphthyl 4-benzyloxycarbonylaminomethylbenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 4-((((Benzyloxy)carbonyl)amino)methyl)benzoic acid | HCID 1479997 | — |
| 反応物 | 6-Carbamimidoylnaphthalen-2-yl methanesulfonate | HCID 13050560 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 6-Amidino-2-naphthyl 4-benzyloxycarbonylaminomethylbenzoate | HCID 13176887 | 46.9% |
反応手順
To 50 ml of dried pyridine, were added 5.1 g of 4-benzyloxycarbonylaminomethylbenzoic acid and 4.4 g of DCC. The mixture was stirred under cooling in ice for 30 minutes, admixed with 5.0 g of 6-amidino-2-naphthol methanesulfonate and stirred for one hour under cooling in ice, then overnight at room temperature. The reaction mixture was filtered* and the filtrate was mixed with ethyl ether. The precipitate which was formed was collected by filtration and recrystallized from a DMF-ethanol mixture to obtain 3.8 g of a white powder of a white powder of 6-amidino-2-naphthyl 4-benzyloxycarbonylaminomethylbenzoate methanesulfonate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04532255 |
| 出典データセット | uspto-grants-1985_07 |
| ORD ID | ord-9e5fc2c2395f4db097b15096d444a484 |
| 出典メモ | uspto-grants-1985_07 |