Nitric Acid → HCID 13489933、化合物

反応式

[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[N+:13]([O-])([OH:15])=[O:14]>>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([N+:13]([O-:15])=[O:14])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]

参加物

反応物 2

HCID 944Nitric Acid

HCID 127123362-Chloro-1-methyl-3-(trifluoromethyl)benzene

生成物 1

HCID 13489933HCID 13489933、化合物収率 98.1%

実験手順

72 gms of the crude mixture of 2, 4, and 6 mono chloro 3-methyl benzotrifluoride (0.37 moles) from Example I was added dropwise to 200 gms of 98% HNO3 at about -5° C. to 0° C. over a period of about 1 hour. After addition, solution was stirred for an additional 20 minutes. The solution was then washed with ice water and solvent extracted with CH2Cl2 to give 87 gms of an amber colored liquid. The liquid was distilled at 100°-110° C./(<0.1 mm) to give 84.5 gms of a yellow colored liquid (96% yield)

後処理

additionAfter addition, solution
washThe solution was then washed with ice water and solvent
extractionextracted with CH2Cl2

出典と根拠

ORDレコード: ord-6d2d8151a06b463a910ec5abd86431d7
出典データセット: uspto-grants-1985_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04532353

反応ノート

読み込み中…

参加物