Water → 4-Chloro-2-ethyl-6-{[4-(propan-2-yl)phenyl]methyl}phenol

HRID 371523ノート

反応式

HRID 371523 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1.[CH:11]([C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1)([CH3:13])[CH3:12].O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:18][C:17]2[CH:20]=[CH:21][C:14]([CH:11]([CH3:13])[CH3:12])=[CH:15][CH:16]=2)[C:5]([OH:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 293574-Chloro-2-EthylphenolHCID 749164-Isopropylbenzyl chloride

生成物 1

HCID 233194194-Chloro-2-ethyl-6-{[4-(propan-2-yl)phenyl]methyl}phenol

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
60 °C

実験手順

117.5 g (0.75 mol) 4-chloro-2-ethylphenol are dissolved with 42.25 g (0.25 mol) 4-isopropylbenzylchloride in 200 ml chloroform. 22.5 g water-free zinc chloride are added thereto for the alkylation reaction. Already at 30° C. a powerful reaction takes place. The entire mixture is after-stirred 5-6 h at 60° C. for completion of the alkylation. After a cooling it is subsequently washed three times each with 200 ml water, and then dried across sodium sulfate, after which the solvent chloroform is driven off.

後処理

  1. customfor the alkylation reaction
  2. customAlready at 30° C. a powerful reaction
  3. washAfter a cooling it is subsequently washed three times each with 200 ml water
  4. dry with materialdried across sodium sulfate

出典と根拠

ORDレコード
ord-fd94c07d2e76497d84a4d35ea1dcde1e
出典データセット
uspto-grants-1985_07
特許番号
US04532367

反応ノート

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