Ethyl 6-acetyl-1,4-benzodioxin-2-carboxylate → Ethyl 6-ethyl-2,3-dihydro-1,4-benzodioxin-2-carboxylate

HRID 37156

反応式

HRID 37156 の反応式
[C:1]([C:4]1[CH:18]=[CH:17][C:7]2[O:8][C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][O:11][C:6]=2[CH:5]=1)(=O)[CH3:2]>C(O)(=O)C.[Pd]>[CH2:1]([C:4]1[CH:18]=[CH:17][C:7]2[O:8][CH:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:10][O:11][C:6]=2[CH:5]=1)[CH3:2]

参加物

4

反応物 1

HCID 11806994Ethyl 6-acetyl-1,4-benzodioxin-2-carboxylate

生成物 1

HCID 15210220Ethyl 6-ethyl-2,3-dihydro-1,4-benzodioxin-2-carboxylate収率 70%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

Hydrogenate a solution of 3 g of ethyl 6-acetyl-1,4-benzodioxin-2-carboxylate in 15 cm3 of acetic acid under hydrogen pressure (50 psi) in the presence of 0.750 g of 5% palladium on carbon. The crude product obtained by concentrating to dryness is purified by chromatography on a silica column (eluant: petroleum ether/diethyl ether, 70:30). Ethyl 6-ethyl-2,3-dihydro-1,4-benzodioxin-2-carboxylate is thereby obtained in a yield of 70%. ##STR29##

後処理

  1. customThe crude product obtained
  2. concentrationby concentrating to dryness
  3. customis purified by chromatography on a silica column (eluant: petroleum ether/diethyl ether, 70:30)

出典と根拠

ORDレコード
ord-a66b2c3fc8ae43888555b4bd5fc2fbdc
出典データセット
uspto-grants-1995_05
特許番号
US05420132

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