Tetrahydrofuran → 1-Diallylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole

HRID 371573ノート

反応式

HRID 371573 の反応式
[CH2:1]([S:5]([C:7]1[N:11]=[CH:10][NH:9][N:8]=1)=[O:6])[CH2:2][CH2:3][CH3:4].[CH2:12]([N:15]([CH2:19][CH:20]=[CH2:21])[C:16](Cl)=[O:17])[CH:13]=[CH2:14].O1CCCC1>C(N(CC)CC)C>[CH2:12]([N:15]([CH2:19][CH:20]=[CH2:21])[C:16]([N:9]1[CH:10]=[N:11][C:7]([S:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[O:6])=[N:8]1)=[O:17])[CH:13]=[CH2:14]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 3449313Diallylcarbamyl chlorideHCID 1784555543-Butylsulphinyl-1,2,4-triazole

生成物 1

HCID 203551101-Diallylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
100 °C

実験手順

A mixture of 5.2 g. 3-butylsulphinyl-1,2,4-triazole, 6.0 g. diallylcarbamoyl chloride, 25 ml. dry tetrahydrofuran and 7.5 ml. dry triethylamine was refluxed under anhydrous conditions for 2 hours. The reaction mixture was filtered to remove triethylamine hydrochloride and the filtrate distilled under reduced pressure to remove solvent. Finally the residue was maintained at 100° C./0.5 mm. for 30 minutes in order to remove all traces of volatile material from the product. The product, 1-diallylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole, was obtained as an oil, nD26 1.5277. Elemental analysis satisfactory.

後処理

  1. additionA mixture of 5.2 g
  2. filtrationThe reaction mixture was filtered
  3. customto remove triethylamine hydrochloride
  4. distillationthe filtrate distilled under reduced pressure
  5. customto remove solvent
  6. customfor 30 minutes in order to remove all traces of volatile material from the product

出典と根拠

ORDレコード
ord-d768bd286f2e40d1963ca1e7638937cb
出典データセット
uspto-grants-1978_05
特許番号
US04087269

反応ノート

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