Tetrahydrofuran → 1-Dipropylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole

HRID 371579ノート

反応式

HRID 371579 の反応式
[CH2:1]([S:5]([C:7]1[N:11]=[CH:10][NH:9][N:8]=1)=[O:6])[CH2:2][CH2:3][CH3:4].[CH2:12]([N:15]([CH2:19][CH2:20][CH3:21])[C:16](Cl)=[O:17])[CH2:13][CH3:14].O1CCCC1>C(N(CC)CC)C>[CH2:12]([N:15]([CH2:19][CH2:20][CH3:21])[C:16]([N:9]1[CH:10]=[N:11][C:7]([S:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[O:6])=[N:8]1)=[O:17])[CH2:13][CH3:14]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 3015348Dipropylcarbamoyl chlorideHCID 1784555543-Butylsulphinyl-1,2,4-triazole

生成物 1

HCID 202901461-Dipropylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

A mixture of 6.9 g. 3-n-butylsulphinyl-1,2,4-triazole, 8.0 ml. dipropylcarbamoyl chloride, 25 ml. dry tetrahydrofuran and 10 ml. dry triethylamine was refluxed under anhydrous conditions for 2 hours. The cooled reaction mixture was filtered and the filtrate distilled under reduced pressure to give an oily residue which subsequently solidified. This solid product was recrystallized from petroleum ether to give 1-dipropylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole, m.p. 39° - 40° C. Elemental analysis satisfactory.

後処理

  1. additionA mixture of 6.9 g
  2. customThe cooled reaction mixture
  3. filtrationwas filtered
  4. distillationthe filtrate distilled under reduced pressure
  5. customto give an oily residue which
  6. customThis solid product was recrystallized from petroleum ether

出典と根拠

ORDレコード
ord-b829549a029a4044af0efdc3bd1bd04c
出典データセット
uspto-grants-1978_05
特許番号
US04087269

反応ノート

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