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Cyclohexylamine → [(Cyclohexylcarbamoyl)methyl]phosphonic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 2-(Dimethoxyphosphoryl)acetic acid | HCID 189964 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | [(Cyclohexylcarbamoyl)methyl]phosphonic acid | HCID 18756975 | 57% |
反応手順
Cyclohexyl amine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide (0.045 mole) was added portionwise. The solution was stirred overnight and the mixture filtered. The filtrate was concentrated to a solid and the solid recrystallized from an appropriate solvent such as methanol. m.p. 180°-3° C.; yield 57%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04087522 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-fa57d76245684623a517de4b633bf7ab |
| 出典メモ | uspto-grants-1978_05 |