Thionyl Chloride → HCID 20355929、化合物

反応式

O[CH:2]([NH:8][C:9](=[O:11])[CH3:10])[C:3]([Cl:7])([Cl:6])[CH2:4][Cl:5].S(Cl)([Cl:14])=O>>[Cl:14][CH:2]([NH:8][C:9](=[O:11])[CH3:10])[C:3]([Cl:7])([Cl:6])[CH2:4][Cl:5]

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 3026119N-(2,2,3-Trichloro-1-hydroxypropyl)acetamide

生成物 1

HCID 20355929HCID 20355929、化合物

実験手順

30 ml of thionyl chloride were poured over 15 gm of N-(1-hydroxy-2,2,3-trichloro-n-propyl)-acetamide, and the mixture was refluxed until the solution became clear. Subsequently, the excess thionyl chloride was distilled off in vacuo, and the residue was recrystallized from benzene/petroleum ether. Upon washing of the crystallizate with petroleum ether, a colorless substance was obtained. Yield: 13.5 gm; m.p. 70°-72° C.

後処理

temperaturethe mixture was refluxed until the solution
distillationSubsequently, the excess thionyl chloride was distilled off in vacuo
customthe residue was recrystallized from benzene/petroleum ether
washUpon washing of the crystallizate with petroleum ether
customa colorless substance was obtained

出典と根拠

ORDレコード: ord-2348e1ba22d6466781408a36d07d89e0
出典データセット: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04087533

反応ノート

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参加物