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Water → HCID 20355912、化合物

HRID 371716
ノート
印刷プレビュー

反応式

HRID 371716 の反応式
Cl[CH:2]([NH:8][C:9](=[O:11])[CH3:10])[C:3]([Cl:7])([Cl:6])[CH2:4][Cl:5].[NH:12]1[CH:16]=[N:15][CH:14]=[N:13]1.C(N(CC)CC)C.O>O1CCCC1>[NH:8]([CH:2]([N:12]1[CH:16]=[N:15][CH:14]=[N:13]1)[C:3]([Cl:7])([Cl:6])[CH2:4][Cl:5])[C:9]([CH3:10])=[O:11]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 92571H-1,2,4-TriazoleHCID 20355929HCID 20355929、化合物

生成物 1

HCID 20355912HCID 20355912、化合物収率 66%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

3.6 gm of N-(1,2,2,3-tetrachloro-n-propyl)-acetamide were dissolved in 30 ml of tetrahydrofuran, and, while stirring, the resulting solution was added dropwise to a solution of 1.05 gm of 1,2,4-triazole and 1.8 gm of triethylamine in 20 ml of tetrahydrofuran. Subsequently, the reaction mixture was stirred for 2 hours at room temperature, then water was added, and the tetrahydrofuran was distilled off in vacuo. The oil thus obtained as a residue crystallized after some time and was recrystallized from methanol/water, yielding 2.7 gm of the compound of the formula ##STR5## having a melting point of 135° C.

後処理

  1. stirringSubsequently, the reaction mixture was stirred for 2 hours at room temperature
  2. distillationthe tetrahydrofuran was distilled off in vacuo
  3. customThe oil thus obtained as a residue
  4. customcrystallized after some time
  5. customwas recrystallized from methanol/water

出典と根拠

ORDレコード
ord-cc7ba7a949c84e358933e619187a4fce
出典データセット
uspto-grants-1978_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04087533

反応ノート

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このページの内容参加物実験手順後処理出典と根拠反応ノート