Trimetazidine → 7-Hydroxy-2-[4-(2,3,4-trimethoxybenzyl)piperazin-1-ylcarbonyl]-2,3-dihydro-1,4-benzodioxin

HRID 37178

反応式

HRID 37178 の反応式
[CH3:1][O:2][C:3]1[C:15]([O:16][CH3:17])=[C:14]([O:18][CH3:19])[CH:13]=[CH:12][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[OH:20][C:21]1[CH:22]=[CH:23][C:24]2[O:29][CH2:28][CH:27]([C:30](O)=[O:31])[O:26][C:25]=2[CH:33]=1>>[OH:20][C:21]1[CH:22]=[CH:23][C:24]2[O:29][CH2:28][CH:27]([C:30]([N:9]3[CH2:10][CH2:11][N:6]([CH2:5][C:4]4[CH:12]=[CH:13][C:14]([O:18][CH3:19])=[C:15]([O:16][CH3:17])[C:3]=4[O:2][CH3:1])[CH2:7][CH2:8]3)=[O:31])[O:26][C:25]=2[CH:33]=1

参加物

3

反応物 2

HCID 21109TrimetazidineHCID 108995517-Hydroxy-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid

生成物 1

HCID 111023127-Hydroxy-2-[4-(2,3,4-trimethoxybenzyl)piperazin-1-ylcarbonyl]-2,3-dihydro-1,4-benzodioxin収率 65%

実験手順

That compound is obtained in a yield of 65% starting from 1-(2,3,4-trimethoxy benzyl)piperazine and 7-hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid.

後処理

  1. customThat compound is obtained in a yield of 65%

出典と根拠

ORDレコード
ord-e2d3a32352c3451a856d603947c115da
出典データセット
uspto-grants-1995_05
特許番号
US05420132

関連ノート

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