Methanol → HCID 178465180、化合物

反応式

[ClH:1].C(OC([NH:12][C@H:13]([C:21]([N:23]1[CH2:32][CH2:31][CH2:30][C@H:24]1[C:25]([N-:27][CH2:28][CH3:29])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:20])[NH2:19])=O)C1C=CC=CC=1.CO.[H][H]>[Pd].O>[ClH:1].[NH2:12][C@H:13]([C:21]([N:23]1[CH2:32][CH2:31][CH2:30][C@H:24]1[C:25]([N-:27][CH2:28][CH3:29])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:19])[NH2:20]

参加物

実験手順

L-Arginyl-L-prolyl-N-ethylamide, hydrochloride is prepared by the following procedure. A solution of 8.7 g. of Nα -benzyloxycarbonyl-L-arginyl-L-prolyl-N-ethylamide hydrochloride in 100 ml. of methanol is stirred with 500 mg. of 20% palladium-on-carbon under one inch water pressure of hydrogen for three hours. The catalyst is removed by filtration and the filtrate evaporated under reduced pressure and at 35°-40° C. The residual foam is used without further purification.