Water → 19-Methoxyandrost-4-ene-3,17-dione

HRID 371815

反応式

HRID 371815 の反応式
[OH:1][CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[CH2:10][CH2:9][C:8]1=[CH:7][C:6](=[O:22])[CH2:5][CH2:4]2.F[B-](F)(F)F.[CH3:28][O+](C)C.O>C(Cl)Cl>[CH3:28][O:1][CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[CH2:10][CH2:9][C:8]1=[CH:7][C:6](=[O:22])[CH2:5][CH2:4]2

参加物

5

反応物 3

HCID 962WaterHCID 25237919-HydroxyandrostenedioneHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)

生成物 1

HCID 5415304219-Methoxyandrost-4-ene-3,17-dione

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

19-Hydroxyandrost-4-ene-3,17-dione is dissolved in methylenechloride and trimethyloxonium fluoroborate added. After stirring at room temperature for a period of two hours, water is added to the reaction mixture, the organic layer is separated, dried over magnesium sulfate and the solvent removed under vacuum. The residue is crystallized from an acetone-hexane solution to yield the desired 19-methoxyandrost-4-ene-3,17-dione.

後処理

  1. customthe organic layer is separated
  2. dry with materialdried over magnesium sulfate
  3. customthe solvent removed under vacuum
  4. customThe residue is crystallized from an acetone-hexane solution

出典と根拠

ORDレコード
ord-375ad16dbc2f48c98abcf840ec02c66b
出典データセット
uspto-grants-1978_05
特許番号
US04087524

関連ノート

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