Sodium Carbonate → 17beta,19-Dihydroxy-1alphamethyl-4-androsten-3-one

HRID 371839ノート

反応式

HRID 371839 の反応式
C(O)(=O)CC.C(O)(=O)CC.[OH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]2[C@H:18]3[C@H:29]([CH2:30][CH2:31][C@:13]12[CH3:14])[C@:26]1([CH2:27][OH:28])[C:21](=[CH:22][C:23](=[O:33])[CH2:24][C@@H:25]1[CH3:32])[CH2:20][CH2:19]3.C(=O)([O-])[O-].[Na+].[Na+]>CO>[OH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]2[C@H:18]3[C@H:29]([CH2:30][CH2:31][C@:13]12[CH3:14])[C@:26]1([CH2:27][OH:28])[C:21](=[CH:22][C:23](=[O:33])[CH2:24][C@@H:25]1[CH3:32])[CH2:20][CH2:19]3

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 8673472917beta,19-Dihydroxy-1alpha-methyl-4-androsten-3-one dipropionate

生成物 1

HCID 2279742517beta,19-Dihydroxy-1alphamethyl-4-androsten-3-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 17β,19-dihydroxy-1α-methyl-4-androsten-3-one dipropionate in methanol is refluxed for two hours with aqueous sodium carbonate. The solvent is removed and the residue dissolved in chloroform. The chloroform solution is washed well with water, dried over magnesium sulfate and evaporated under vacuum. The residue which remains in crystallized from acetonitrile to yield 17β,19-dihydroxy-1α-methyl-4-androsten-3-one.

後処理

  1. customThe solvent is removed
  2. dissolutionthe residue dissolved in chloroform
  3. washThe chloroform solution is washed well with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated under vacuum
  6. customin crystallized from acetonitrile

出典と根拠

ORDレコード
ord-f8042fc939c3450a8463ef2ff819279b
出典データセット
uspto-grants-1978_05
特許番号
US04087524

反応ノート

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