2-Methylbenzoic acid → 2-Methylbenzoyl chloride
反応式
[C:1]1([CH3:10])[C:2]([C:7](O)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.C(Cl)(=O)C([Cl:14])=O>C1C=CC=CC=1.CN(C=O)C>[CH3:10][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:14])=[O:8]参加物
5
実験手順
Meanwhile, the 2-methylbenzoyl chloride acylating agent was prepared by suspending 4.750 g (42.2 mmol) of o-toluic acid in 100 ml benzene. To this solution was added 2.0 equiv. (7.37 ml) of oxalyl chloride, dropwise via a pressure-equalizing dropping funnel at 0° C. DMF (2-3 drops) was added to the reaction mixture catalytically and the ice bath was removed. The progress of the reaction was monitored via infrared spectroscopy. The solvent was removed by rotary vacuum evaporation and the residual oil was pumped down under high vacuum overnight.
後処理
- customat 0° C
- customthe ice bath was removed
- customThe solvent was removed by rotary vacuum evaporation
- customwas pumped down under high vacuum overnight
出典と根拠
- ORDレコード
- ord-3f648e2bc73d4ea2a99c31b12348376b
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05420134
反応ノート
読み込み中…