2-Methylbenzoic acid → 2-Methylbenzoyl chloride

HRID 37186

反応式

HRID 37186 の反応式
[C:1]1([CH3:10])[C:2]([C:7](O)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.C(Cl)(=O)C([Cl:14])=O>C1C=CC=CC=1.CN(C=O)C>[CH3:10][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:14])=[O:8]

参加物

5

反応物 2

HCID 83732-Methylbenzoic acidHCID 65578Oxalyl chloride

生成物 1

HCID 702762-Methylbenzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 241Benzene溶媒

実験手順

Meanwhile, the 2-methylbenzoyl chloride acylating agent was prepared by suspending 4.750 g (42.2 mmol) of o-toluic acid in 100 ml benzene. To this solution was added 2.0 equiv. (7.37 ml) of oxalyl chloride, dropwise via a pressure-equalizing dropping funnel at 0° C. DMF (2-3 drops) was added to the reaction mixture catalytically and the ice bath was removed. The progress of the reaction was monitored via infrared spectroscopy. The solvent was removed by rotary vacuum evaporation and the residual oil was pumped down under high vacuum overnight.

後処理

  1. customat 0° C
  2. customthe ice bath was removed
  3. customThe solvent was removed by rotary vacuum evaporation
  4. customwas pumped down under high vacuum overnight

出典と根拠

ORDレコード
ord-3f648e2bc73d4ea2a99c31b12348376b
出典データセット
uspto-grants-1995_05
特許番号
US05420134

関連ノート

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