関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Bis(trimethylsilyl)acetylene | HCID 84564 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | methyl N-carbethoxy-2-chloroglycinate | HCID 15571344 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 2-trimethylsilylacetylene 2-carbethoxyaminoacetate | HCID 86735698 | — |
反応手順
To 19.5 g (0.1 M) of methyl N-carbethoxy-2-chloroglycinate and 17.0 g (0.1 M) of bis-trimethylsilyl acetylene in 200 ml of methylene chloride at 0° C is added 13.5 g (0.1 M) of aluminum chloride and the reaction mixture is allowed to warm to 25° C. After 24 hours at 25° C water is carefully added to the mixture which is then extracted with methylene chloride. The combined organic solutions are dried over magnesium sulfate, concentrated and distilled with the b.p. 100°/0.15 mm fraction collected to give methyl 2-trimethylsilylacetylene-2-carbethoxyaminoacetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04088667 |
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| 出典データセット | uspto-grants-1978_05 |
|---|
| ORD ID | ord-5a21285654ca41feb8eb945e6b016e70 |
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| 出典メモ | uspto-grants-1978_05 |
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