Hydrazine hydrate (1:1) → 6-(3-Chloro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:5]([CH2:7][CH2:8][C:9](O)=[O:10])=O.O.[NH2:18][NH2:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[CH2:7][CH2:8][C:9](=[O:10])[NH:18][N:19]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

参加物

反応物 2

HCID 24654Hydrazine hydrate (1:1)

HCID 100603124-(3-Chloro-4-methoxyphenyl)-4-oxobutanoic acid

生成物 1

HCID 108238766-(3-Chloro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone収率 84%

実験手順

This compound was prepared in 84% yield by reaction of 3-(3-chloro-4-methoxybenzoyl)propionic acid with hydrazine hydrate in ethanolic solution at reflux temperature for 5 hours. It had mp 194°-195° C after crystallisation from ethanol.

後処理

temperatureat reflux temperature for 5 hours
customafter crystallisation from ethanol

出典と根拠

ORDレコード: ord-a74367ec920b4cb09440d2bd0f62957d
出典データセット: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04088762

反応ノート

読み込み中…

参加物