2-Aminopyridine → 2-Methylimidazo[1,2-a]pyridine
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([C:12]1C(CC2C=CC(C3C(C(OC(C)(C)C)=O)=CC=CC=3)=CC=2)=C2CCCCN2N=1)[CH2:9]CC.BrCC(=O)C>CC(C)=O>[CH3:12][C:8]1[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]2[CH:9]=1参加物
5
実験手順
A mixture of 5 g of 2-amino pyridine and 250 ml of acetone were added at ambient temperature to a mixture of 7.25 g of 1 bromo 2-propanone and 20 ml of acetone and the mixture was refluxed for 30 minutes. Using the procedure of Stage C of Example 22, 5.3 g of the expected product were obtained in the form of an orange oil.
後処理
- temperaturethe mixture was refluxed for 30 minutes
出典と根拠
- ORDレコード
- ord-a3c2d8350f0a4600b896fc04423ca462
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05420138
反応ノート
読み込み中…