Bromoform → Methyl 2-bromothiazole-5-carboxylate
反応式
[N+]([O-])(OCCCCC)=O.[CH:10]([Br:13])(Br)Br.NC1[S:16][C:17]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][N:19]=1>>[Br:13][C:10]1[S:16][C:17]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][N:19]=1参加物
4
実験手順
A mixture containing 100 g. of amyl nitrate and 600 ml. of bromoform is warmed to 70° C and then a total of 100 g. of 2-amino-5-methoxycarbonylthiazole is added portionwise with rapid stirring while maintaining the temperature at about 95°-100° C. The mixture is then stirred for an additional ten minutes at this temperature and then the bromoform is distilled off under vacuum. The residue is chromatographed on silica gel yielding 2-bromo-5-methoxycarbonylthiazole.
後処理
- additionA mixture containing 100 g
- temperaturewhile maintaining the temperature at about 95°-100° C
- stirringThe mixture is then stirred for an additional ten minutes at this temperature
- distillationthe bromoform is distilled off under vacuum
- customThe residue is chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-f18bc3313aa14100afdb4d913b8f62e3
- 出典データセット
- uspto-grants-1978_05
- 特許番号
- US04089865
反応ノート
読み込み中…