Water → (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl acetate

HRID 37262

反応式

HRID 37262 の反応式
[OH:1][CH2:2][CH:3]1[CH2:7][O:6][C:5]([CH3:9])([CH3:8])[O:4]1.N1C=CC=CC=1.[C:16](OC(=O)C)(=[O:18])[CH3:17].O>ClCCl.C(OCC)(=O)C>[C:16]([O:1][CH2:2][CH:3]1[CH2:7][O:6][C:5]([CH3:9])([CH3:8])[O:4]1)(=[O:18])[CH3:17]

参加物

7

反応物 4

HCID 962WaterHCID 1049PyridineHCID 7528SolketalHCID 7918Acetic Anhydride

生成物 1

HCID 252333(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl acetate収率 85.4%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a mixture of 4-hydroxymethyl-2,2-dimethyl-1,3-dioxolane (5.35 g) and pyridine (15.65 g) in dichloromethane (200 ml) was added acetic anhydride (20.56 g), and the mixture was stirred at ambient temperature for 12 hours. The mixture was poured into a mixture of water and ethyl acetate. The organic layer was separated, washed with saturated aqueous sodium hydrogen carbonate and brine successively, dried over magnesium sulfate, and evaporated in vacuo to give 4-acetoxymethyl-2,2-dimethyl-1,3-dioxolane (6.02 g).

後処理

  1. customThe organic layer was separated
  2. washwashed with saturated aqueous sodium hydrogen carbonate and brine successively
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-d89cf0c6c2db4b6a9bf43154be9933c2
出典データセット
uspto-grants-1995_05
特許番号
US05420122

関連ノート

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