Methylamine → 4-Chloro-2-isopropylamino-6-methylamino-5-pyrimidinecarbonitrile

反応式

[CH3:1]N.Cl[C:4]1[C:9]([C:10]#[N:11])=[C:8]([Cl:12])[N:7]=[C:6]([NH:13][CH2:14][CH3:15])[N:5]=1.[CH:16]([NH2:19])(C)C>>[Cl:12][C:8]1[C:9]([C:10]#[N:11])=[C:4]([NH:19][CH3:16])[N:5]=[C:6]([NH:13][CH:14]([CH3:15])[CH3:1])[N:7]=1

参加物

反応物 3

HCID 6329Methylamine

HCID 6363Isopropylamine

HCID 205102564,6-Dichloro-2-ethylamino-5-pyrimidinecarbonitrile

生成物 1

HCID 205102014-Chloro-2-isopropylamino-6-methylamino-5-pyrimidinecarbonitrile

実験手順

This compound was prepared in the manner of Example XVII, substituting 4,6-dichloro-2-isopropylamino-5-pyrimidinecarbonitrile and aqueous 40% methylamine for 4,6-dichloro-2-ethylamino-5-pyrimidinecarbonitrile and isopropylamine. The reaction product was recrystallized from methylcyclohexane to give 4-chloro-2-isopropylamino-6-methylamino-5-pyrimidinecarbonitrile; mp, 170°-173°.