Ammonia → 6-Amino-4-chloro-2-isopropylamino-5-pyrimidinecarbonitrile

HRID 372649ノート

反応式

HRID 372649 の反応式
[NH3:1].[Cl:2][C:3]1[C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=[C:5](NCC)[N:4]=1.[CH:15]([NH2:18])([CH3:17])[CH3:16]>>[NH2:1][C:7]1[N:6]=[C:5]([NH:18][CH:15]([CH3:17])[CH3:16])[N:4]=[C:3]([Cl:2])[C:8]=1[C:9]#[N:10]

参加物

4

反応物 3

HCID 222AmmoniaHCID 6363IsopropylamineHCID 205102564,6-Dichloro-2-ethylamino-5-pyrimidinecarbonitrile

生成物 1

HCID 205102266-Amino-4-chloro-2-isopropylamino-5-pyrimidinecarbonitrile

実験手順

This compound was prepared in the manner of Example XVII, substituting 4,6-dichloro-2-isopropylamino-5-pyrimidinecarbonitrile and aqueous ammonia for 4,6-dichloro-2-ethylamino-5-pyrimidinecarbonitrile and isopropylamine. The reaction product was recrystallized from benzene to give 6-amino-4-chloro-2-isopropylamino-5-pyrimidinecarbonitrile; mp, 162°-165°.

後処理

  1. customThis compound was prepared in the manner of Example XVII
  2. customThe reaction product was recrystallized from benzene

出典と根拠

ORDレコード
ord-fe8094ed5f3c4599b94061ea24c0af93
出典データセット
uspto-grants-1978_05
特許番号
US04092150

反応ノート

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