(+-)-2-Butanol → HCID 12783677、化合物

HRID 372674ノート

反応式

HRID 372674 の反応式
[Na].Cl[C:3]1[NH:8][C:7](=[O:9])[C:6]([F:10])=[CH:5][N:4]=1.[CH:11]([OH:15])([CH2:13][CH3:14])[CH3:12]>>[CH:11]([O:15][C:3]1[NH:8][C:7](=[O:9])[C:6]([F:10])=[CH:5][N:4]=1)([CH2:13][CH3:14])[CH3:12]

参加物

4

反応物 3

HCID 6568(+-)-2-ButanolHCID 2553942-Chloro-5-fluoropyrimidin-4-olHCID 5360545Sodium

生成物 1

HCID 12783677HCID 12783677、化合物収率 91.4%

実験手順

A 300 ml quantity of absolute sec-butanol, 5.8 g of metal sodium and 14.9 g of 2-chloro-5-fluoropyrimidin-4-one are treated in the same manner as in Example 6 to obtain crystals, which are then recrystallized from a water-ethanol mixture to give 17.0 g of white crystalline 2-sec-butoxy-5-fluoropyrimidin-4-one in a yield of 91.4%, m.p. 104°-105° C.

後処理

  1. customto obtain crystals, which
  2. customare then recrystallized from a water-ethanol mixture

出典と根拠

ORDレコード
ord-ae6d5fe4d5744678bc8b9bfb8c08b3be
出典データセット
uspto-grants-1978_05
特許番号
US04092313

反応ノート

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