Ammonium Hydroxide → 5-methyl-6-phenyl-3(2H)-Pyridazinone
反応式
[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[N:6][NH:5][C:4](=[O:15])[CH:3]=1.[OH-].[NH4+].[H][H]>[Pd].C(O)C>[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][NH:5][C:4](=[O:15])[CH:3]=1参加物
6
反応条件
- 温度
- 50 °C
実験手順
A 10.0 g. portion of 5-methyl-6-p-bromophenyl-3(2H)-pyridazinone and 1.0 g. of 10% palladium on carbon catalyst in 150 ml. of ethanol and 50 ml. of ammonium hydroxide is shaken under 40 lb. of hydrogen pressure for 4 hours in a Parr bottle, heated to 50° C. with an outside jacket. The reaction mixture is suction filtered and the filtrate concentrated to a white solid which is washed with water and air dried to afford 5-methyl-6-phenyl-3(2H)-pyridazinone as white crystals.
後処理
- filtrationfiltered
- concentrationthe filtrate concentrated to a white solid which
- washis washed with water and air
- customdried
出典と根拠
- ORDレコード
- ord-d49d3470fa454469ba9a7803968e1111
- 出典データセット
- uspto-grants-1978_05
- 特許番号
- US04092311
反応ノート
読み込み中…