5-Bromo-2-hydroxypyridine → 5-(Phenylthio)-2-pyridone
反応式
Br[C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[S-:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[K+]>CN1CCCC1=O.O>[C:10]1([S:9][C:2]2[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1参加物
5
実験手順
A solution of 5-bromo-2-pyridone (17.3 g 0.1 mole) in N-methylpyrrolidinone (250 ml.) and potassium thiophenoxide (18.1 g, 0.12 mole) is heated at reflux for 12 hours under a nitrogen atmosphere. The reaction mixture is cooled and diluted with water. The product is collected by filtration, washed with water and dried to yeild 5-(phenylthio)-2-pyridone.
後処理
- temperatureat reflux for 12 hours under a nitrogen atmosphere
- temperatureThe reaction mixture is cooled
- filtrationThe product is collected by filtration
- washwashed with water
- dry with materialdried to yeild 5-(phenylthio)-2-pyridone
出典と根拠
- ORDレコード
- ord-9ca0a3824ae444c9b4fee4d9894b9db9
- 出典データセット
- uspto-grants-1978_05
- 特許番号
- US04092321
反応ノート
読み込み中…