Sodium Chloride → HCID 20556552、化合物

HRID 372818ノート

反応式

HRID 372818 の反応式
[Na].[C:2]([O:8][CH3:9])(=[O:7])[CH2:3][C:4]([CH3:6])=[O:5].[CH2:10]([C:15]1[C:16](=[O:20])[CH2:17][CH2:18][CH:19]=1)[CH2:11][CH2:12][CH2:13][CH3:14].[Cl-].[Na+]>C(O)(=O)C.CO>[CH2:10]([C:15]1([CH:3]([C:2]([O:8][CH3:9])=[O:7])[C:4](=[O:5])[CH3:6])[CH2:19][CH2:18][CH2:17][C:16]1=[O:20])[CH2:11][CH2:12][CH2:13][CH3:14]

参加物

7

反応物 4

HCID 5234Sodium ChlorideHCID 7757Methyl acetoacetateHCID 1175492-Cyclopenten-1-one, 2-pentyl-HCID 5360545Sodium

生成物 1

HCID 20556552HCID 20556552、化合物収率 70.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 887Methanol溶媒

実験手順

750 ml of absolute methanol was introduced into a 2 liter flask. 17.3 g of sodium were added thereto. 580 g of methyl acetoacetate and 456 g of 2-pentyl-cyclopent-2-en-1-one were then added and the mixture was allowed to stand for 48 hours at the ambient temperature. The reaction product was neutralised with 45 g of acetic acid and then poured into 3 liters of a 10% aqueous sodium chloride solution. The product was then worked up as described in Example 1 (a). There were thus obtained 567 g (yield = 70%) of 2-n-pentyl-(1-carbomethoxy-2-oxopropyl)-1-cyclopentanone having: nD20 = 1.4702, d420 = 1.0545.

出典と根拠

ORDレコード
ord-f7a227ba79cb417db3dd65130518f47b
出典データセット
uspto-grants-1978_05
特許番号
US04092362

反応ノート

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