Hydrochloric Acid → N-(2,6-diethylphenyl)-N'-(4-phenylcyclohexyl)urea

HRID 37292

反応式

HRID 37292 の反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][CH3:23])[C:17]=1[N:24]=[C:25]=[O:26])[CH3:15].N1C=CC=CC=1.Cl>ClCCl>[CH2:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][CH3:23])[C:17]=1[NH:24][C:25]([NH:13][CH:10]1[CH2:9][CH2:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1)=[O:26])[CH3:15]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 298974-PhenylcyclohexylamineHCID 51531832,6-Diethylphenyl isocyanate

生成物 1

HCID 19935160N-(2,6-diethylphenyl)-N'-(4-phenylcyclohexyl)urea

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1 g of 4-phenylcyclohexylamine in 10 ml of dichloromethane was added 2,6-diethylphenylisocyanate dropwise in the presence of pyridine and the mixture was stirred for 2 hours at room temperature. To the resultant mixture was added 30 ml of diluted hydrochloric acid and the solution was extracted with chloroform. The extract was washed with water, aqueous sodium hydrogencarbonate solution and saturated brine, and then dried over magnesium sulfate. The solvent was distilled away and the residue was crystallized from methanol to give 0.4 g of N-(2,6-diethylphenyl)-N'-(4-phenylcyclohexyl)urea, melting at 247°-249° C.

後処理

  1. extractionthe solution was extracted with chloroform
  2. washThe extract was washed with water, aqueous sodium hydrogencarbonate solution and saturated brine
  3. dry with materialdried over magnesium sulfate
  4. distillationThe solvent was distilled away
  5. customthe residue was crystallized from methanol

出典と根拠

ORDレコード
ord-c23ebd5f61fc415c985902eea7eba4c6
出典データセット
uspto-grants-1995_05
特許番号
US05420164

関連ノート

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