Ethylenediamine → Dodecanamide, N-(2-aminoethyl)-

HRID 373197

反応式

HRID 373197 の反応式
[C:1]([O:14]CC)(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH2:17]([NH2:20])[CH2:18][NH2:19]>O1CCCC1>[NH2:19][CH2:18][CH2:17][NH:20][C:1](=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

参加物

4

反応物 2

HCID 3301EthylenediamineHCID 7800Ethyl Dodecanoate

生成物 1

HCID 82394Dodecanamide, N-(2-aminoethyl)-収率 44.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
100 °C

実験手順

A solution of 23 g of ethyl dodecanoate and 62.7 g of ethylenediamine in 100 ml of tetrahydrofuran (THF) was refluxed for 3 hours and the excess THF was distilled off. The reaction mixture was heated at 100° C. for 16 hours, cooled to room temperature, poured into cold water and extracted with ether. After drying, the organic solution was concentrated to give 15.7 g of crude product and this was recrystallized from ether-hexane to give 10.9 g of pure product, m.p. 64°-66° C.

後処理

  1. distillationthe excess THF was distilled off
  2. temperaturecooled to room temperature
  3. additionpoured into cold water
  4. extractionextracted with ether
  5. customAfter drying
  6. concentrationthe organic solution was concentrated
  7. customto give 15.7 g of crude product
  8. customthis was recrystallized from ether-hexane

出典と根拠

ORDレコード
ord-4ba5e978f6544351a643c1f9b3b0d08d
出典データセット
uspto-grants-1992_11
特許番号
US05162315

関連ノート

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