Cyclohexylisopropylamine → HCID 54014012、化合物

HRID 373207

反応式

HRID 373207 の反応式
C([Li])CCC.C(NC1CCCCC1)(C)C.C[Si]([CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(C)C.[F:26][C:27]([F:53])([F:52])[C:28]1[CH:29]=[C:30]([CH:45]=[C:46]([C:48]([F:51])([F:50])[F:49])[CH:47]=1)[CH2:31][O:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH:39]=[CH:40][C:41](=O)[CH2:42][CH3:43]>CCCCCC.O1CCCC1>[F:26][C:27]([F:52])([F:53])[C:28]1[CH:29]=[C:30]([CH:45]=[C:46]([C:48]([F:51])([F:50])[F:49])[CH:47]=1)[CH2:31][O:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH:39]=[CH:40][C:41]([CH2:42][CH3:43])=[CH:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

参加物

7

反応物 4

HCID 62386CyclohexylisopropylamineHCID 77687Ethyl trimethylsilylacetateHCID 57249347HCID 57249347、化合物HCID 178418339Butyllithium

生成物 1

HCID 54014012HCID 54014012、化合物

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8058Hexane溶媒

実験手順

n-Butyl lithium (4.99 mmol) in hexane was added to N-isopropyl cyclohexylamine (0.69 g, 4.88 mmol, Aldrich Chem Co.) in dry tetrahydrofuran (20 ml) at -78° under nitrogen. After 15 mins, ethyl trimethylsilylacetate (0.78 g, 4.88 mmol, Fluka Chem. Co.) was added. After a further 10 mins, 11-(3',5'-bistrifluoromethylbenzyloxy) undeca-4-ene-3-one (1 g, 2.44 mmol) was added and the temperature was allowed to reach room temperature. After conventional work-up and chromatography on silica, ethyl 11-(3',5'-bistrifluoromethylbenzyloxy)-3-ethyl-undeca-2, 4- dienoate was obtained as a mixture of two isomers.

後処理

  1. waitAfter a further 10 mins
  2. customto reach room temperature

出典と根拠

ORDレコード
ord-f067143e609144788c135f6d17afa0a3
出典データセット
uspto-grants-1992_11
特許番号
US05162367

関連ノート

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