1-Propanol → 2-{1-[4-(2-Methoxyphenyl)piperazinyl]methyl}-3-benzenepropanoic acid

HRID 37365

反応式

HRID 37365 の反応式
[C:1]1([CH2:7][C:8](=C)[C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.[CH2:27](O)CC>>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][N:24]([CH2:27][C:2]2[C:1]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:23][CH2:22]1

参加物

4

反応物 3

HCID 10311-PropanolHCID 13461-(2-Methoxyphenyl)piperazineHCID 3035712-Benzylacrylic Acid

生成物 1

HCID 194335722-{1-[4-(2-Methoxyphenyl)piperazinyl]methyl}-3-benzenepropanoic acid

実験手順

2-(Phenylmethyl)propenoic acid (Mannich and Ganz, Chem. Ber., 1922, 55, 34867) (2.00 g, 12.35 mmol) and 1-(2-methoxyphenyl)piperazine (2.37 g, 12.35 mmol) in propanol (25 ml) were heated under reflux for 18 hours, cooled to room temperature, and evaporated in vacuo. The residue was triturated with acetone and ether to give the product (0.80 g) as a colourless powder, m.p. 155°-158°. (Found: C, 71.6; H, 7.4; N, 7.6. C21H26N2O3 requires C, 71.2; H, 7.3; N, 7.9%.)

後処理

  1. temperatureunder reflux for 18 hours
  2. customevaporated in vacuo
  3. customThe residue was triturated with acetone and ether

出典と根拠

ORDレコード
ord-0a52dcde0a794f1386fc3d683b184db6
出典データセット
uspto-grants-1995_05
特許番号
US05420278

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