2,6-Dichlorophenol → Phenol, 2,6-dichloro-4-fluoro-

HRID 373677

反応式

HRID 373677 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[OH:9].[F:10][B-](F)(F)F.F[N+]1C(C(Cl)(Cl)Cl)=CC=CC=1Cl>ClC(Cl)CCl>[F:10][C:6]1[CH:7]=[C:2]([Cl:1])[C:3]([OH:9])=[C:4]([Cl:8])[CH:5]=1

参加物

4

反応物 2

HCID 68992,6-DichlorophenolHCID 11078229N-fluoro-2-chloro-6-(trichloromethyl)pyridinium fluoroborate

生成物 1

HCID 94950Phenol, 2,6-dichloro-4-fluoro-

試薬・触媒・溶媒 1

HCID 65741,1,2-Trichloroethane溶媒

反応条件

温度
55 °C

実験手順

A mixture of 0.82 g of 2,6-dichlorophenol, 1.67 g of N-fluoro-2-chloro-6-(trichloromethyl)pyridinium fluoroborate, and 40 ml of 1,1,2-trichloroethane was placed in a 100 ml 3-necked round bottomed flask equipped with a magnetic stirring bar, a thermometer, and a reflux condenser. The mixture was heated to 55° C. and allowed to react at that temperature for 8 hours under nitrogen. The mixture was then allowed to cool. Analysis by standardized gas-liquid chromatography using a mass spectrometer detector indicated that the title product was present in 24 percent conversion. The product identity was confirmed by its known 19F and 1H NMR spectra.

後処理

  1. customwas placed in a 100 ml 3-necked round bottomed flask
  2. customequipped with a magnetic stirring bar
  3. customto react at that temperature for 8 hours under nitrogen
  4. temperatureto cool

出典と根拠

ORDレコード
ord-cded21eddd694416bf0fea2a1b623049
出典データセット
uspto-grants-1992_11
特許番号
US05164502

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