Acetone → Diethyl 3,4-dihydroxybutylphosphonate

HRID 373885ノート

反応式

HRID 373885 の反応式
[CH2:1]([P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8])[CH2:2]C=C.C[N+]1([O-])[CH2:19][CH2:18][O:17]CC1.CC(C)=[O:23]>O.[Os](=O)(=O)(=O)=O>[OH:23][CH:19]([CH2:18][OH:17])[CH2:2][CH2:1][P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8]

参加物

6

反応物 3

HCID 180AcetoneHCID 82029Methyl morpholine oxideHCID 10997850Diethyl 3-butenylphosphonate

生成物 1

HCID 19808663Diethyl 3,4-dihydroxybutylphosphonate収率 71%

試薬・触媒・溶媒 2

HCID 30318Osmium Tetroxide触媒HCID 962Water溶媒

実験手順

To a solution of diethyl but-3-enylphosphonate (10.2 g, 0.053 mol) in acetone (200 ml) and water (40 ml), was added a trace of osmium tetroxide (1 mg). After stirring for 10 minutes at ambient temperature, 4-methylmorpholine-N-oxide (10.75 g, 0.079 mol) was added in one portion. Stirring was continued overnight under an atmosphere of nitrogen. The solution was concentrated under reduced pressure, and final traces of water removed by azeotroping with benzene and ethanol. The residual brown oil was chromatographed on silica gel (dichloromethane-methanol, 95:5 as eluant) to give the title compound as an oil (8.5 g, 71%). IR: υmax (film), 3400, 3000, 2940, 2880, 1450, 1400, 1230, 1170, 1070, 1030, 970, 820, 790 cm-1. 1H NMR: δH ((CD3)2SO) 1.25 (6H, t, J=8Hz, (OCH2CH3)2), 1.3-2.05 (4H, m, CH2CH2P), 3.1-3.5 (3H, m, HOCH2CH(OH)), 4.0 (4H, m, (OCH2CH3)2), 4.6 (2H, m, D2O exchangeable, HOCH2CH(OH)). Found: C, 42.57; H, 8.56%. C8H19O5P requires: C, 42.47; H, 8.46%. m/z:C8H20O5P requires 227.1048; observed: 227.1045 (MH+).

後処理

  1. stirringStirring
  2. waitwas continued overnight under an atmosphere of nitrogen
  3. concentrationThe solution was concentrated under reduced pressure
  4. customfinal traces of water removed
  5. customby azeotroping with benzene and ethanol
  6. customThe residual brown oil was chromatographed on silica gel (dichloromethane-methanol, 95:5 as eluant)

出典と根拠

ORDレコード
ord-a6cc4d4ed7a04d11adaf2dfa16fe62e4
出典データセット
uspto-grants-1992_11
特許番号
US05166198

反応ノート

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